Salt of yohimbine.



erystallizations from hot water.

UNITED STATES PATENT OFFICE.

LEOPOLD SPIEGEL, or BERLIN, GERMANY, ASSIGNOR TO OHEMISGHE FABRIK eUEsTRoW, or GUESTROW, GERMANY, A FIRM.

SALT OF YOHIMBINE.

SPECIFICATION forming part of Letters Patent No. 716,776, dated December Application filed February 2, 1901. Serial No. 45,724. (No specimens.)

To all whom it nearly concern;

Be it known that I, LEOPOLD SPIEGEL, a subject of the Emperor of Germany, residing at Berlin, Germany, have invented acertain new and useful Process of Producing Salts of Yohimbine, of which the following is a specification.

This invention relates to the production of the salts of yohimbine, a new alkaloid, the characteristics and origin of which have been described and the process of manufacturing which has been claimed in my application for Letters Patent, Serial No. 23,021, filed J nly 9, 1900.

The salts of yohimbine are used in medicine as stimulants, acting on the nerve-centers and the heart. The normal dose of the chlorhydrate is 0.005 gram or ten drops of a one-per-cent. solution. This may be given three times daily or 0.015 gram perdiem. The maximal dose should not exceed 0.0225 gram per diem, as larger doses act poisonous. The salts of yohimblne may be taken in aqueous solution or in carefully-dosed tablets, or the solution may be injected subcutaneously.

The salts of yohimbine are prepared by suspending ihe alkaloid in water and adding an equivalent quantity of the acid. The alkaloid may also be previously dissolved in a solvent which will mix with water, such as alcohol, or one salt may be used to obtain another by double decomposition. Thus the chlorid of yohimbine may be prepared from its sulfate by the action of barium chlorid. As all these salts of yohimbine are more or less soluble in water, they are obtained pure by repeated re- In the formation of these salts the acid is added, but at the same time there evades one molecule of water, so that, in fact, the acid radical is substituted for hydroxyl (HO) under forma tion of water:

Thus all salts of yohimbine correspond to the general formula, (G H N )11Hu.R, in which n expresses the molecular value of the acid radical R.

Among others the following salts of yohimbine have been prepared: yohimbine chlorid, O H N O .HOl, minute white needles, melting at 300 centigrade; yohimbine nitrate, O H N O .HNO colorless ribbed prisms, (fiecomposed at 292 centigrade without melting; yohimbine phosphate, (G H N O .H .PO fine concentrically-grouped needles, melting at 263 centigrade; yohimloine citrate,

substantially as described.

In testimony whereof I affix my signature in presence of twowitnesses.

' LEOPOLD SPIEGEL.

\Vitnesses:

HENRY HASPER, WoLDEMAR HAUPT. 

